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Target
Hexokinase-4
Ligand
BDBM50041653
Substrate
n/a
Meas. Tech.
ChEMBL_1445934 (CHEMBL3377918)
EC50
2760±n/a nM
Citation
 Du, X; Hinklin, RJ; Xiong, Y; Dransfield, P; Park, J; Kohn, TJ; Pattaropong, V; Lai, S; Fu, Z; Jiao, X; Chow, D; Jin, L; Davda, J; Veniant, MM; Anderson, DA; Baer, BR; Bencsik, JR; Boyd, SA; Chicarelli, MJ; Mohr, PJ; Wang, B; Condroski, KR; DeWolf, WE; Conn, M; Tran, T; Yang, J; Aicher, TD; Medina, JC; Coward, P; Houze, JB C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators. ACS Med Chem Lett 5:1284-9 (2014) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50041653
Synonyms:
CHEMBL3358441
Type:
Small organic molecule
Emp. Form.:
C19H27N5O3
Mol. Mass.:
373.4494
SMILES:
CNC(=O)Nc1ncc(CC2CCOCC2)cc1Oc1ccnn1C(C)C
Structure:
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