Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50252946
Substrate
n/a
Meas. Tech.
ChEMBL_1459860 (CHEMBL3367283)
Ki
0.320000±n/a nM
Citation
 Miyata, K; Möller, G; Schepmann, D; Wünsch, B Pyridine analogues of spirocyclics1 receptor ligands. Bioorg Med Chem 22:4277-84 (2014) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50252946
Synonyms:
1-Benzyl-6-methoxy-6,7-dihydrospiro[piperidine-4,4-thieno[3.2-c]pyran] | CHEMBL521657
Type:
Small organic molecule
Emp. Form.:
C19H23NO2S
Mol. Mass.:
329.456
SMILES:
COC1Cc2sccc2C2(CCN(Cc3ccccc3)CC2)O1
Structure:
Search PDB for entries with ligand similarity: