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Target
Pyroglutamylated RF-amide peptide receptor
Ligand
BDBM50045830
Substrate
n/a
Meas. Tech.
ChEMBL_1456341 (CHEMBL3368109)
IC50
40±n/a nM
Citation
 Georgsson, J; Bergström, F; Nordqvist, A; Watson, MJ; Blundell, CD; Johansson, MJ; Petersson, AU; Yuan, ZQ; Zhou, Y; Kristensson, L; Kakol-Palm, D; Tyrchan, C; Wellner, E; Bauer, U; Brodin, P; Svensson Henriksson, A GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26. J Med Chem 57:5935-48 (2014) [PubMed]  Article 
Target
Name:
Pyroglutamylated RF-amide peptide receptor
Synonyms:
GPR103 | Pyroglutamylated RFamide peptide receptor | QRFPR | QRFPR_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49508.46
Organism:
Homo sapiens (Human)
Description:
GPR103 0 HUMAN::Q96P65
Residue:
431
Sequence:
MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
  
Inhibitor
Name:
BDBM50045830
Synonyms:
CHEMBL3314362
Type:
Small organic molecule
Emp. Form.:
C23H26ClN3O
Mol. Mass.:
395.925
SMILES:
CN(C)Cc1cc2CCN(Cc2cc1C)C(=O)c1cc2cc(Cl)ccc2n1C
Structure:
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