Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM50248139
Substrate
n/a
Meas. Tech.
ChEMBL_1453809 (CHEMBL3365186)
EC50
220±n/a nM
Citation
 Di Fruscia, P; He, Y; Koenig, M; Tabrizifard, S; Nieto, A; McDonald, PH; Kamenecka, TM The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1). Bioorg Med Chem Lett 24:3974-8 (2014) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50248139
Synonyms:
(2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid | CHEMBL462830
Type:
Small organic molecule
Emp. Form.:
C26H25ClN4O4
Mol. Mass.:
492.954
SMILES:
COc1ccccc1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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