Reaction Details Report a problem with these data
Target
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Ligand
BDBM50056954
Substrate
n/a
Meas. Tech.
ChEMBL_1455849 (CHEMBL3362303)
Ki
500±n/a nM
Citation
 Amiable, C; Paoletti, J; Haouz, A; Padilla, A; Labesse, G; Kaminski, PA; Pochet, S 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities. Eur J Med Chem 85:418-37 (2014) [PubMed]  Article 
Target
Name:
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Synonyms:
C6orf108 | C6orf108 | DNPH1 | DNPH1_HUMAN | RCL | c-Myc-responsive protein RCL
Type:
PROTEIN
Mol. Mass.:
19102.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109542
Residue:
174
Sequence:
MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT
  
Inhibitor
Name:
BDBM50056954
Synonyms:
CHEMBL3331381
Type:
Small organic molecule
Emp. Form.:
C27H25N4O8P
Mol. Mass.:
564.4832
SMILES:
COc1ccc2cc(ccc2c1)-c1cccc(c1)-c1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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