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Target
Stearoyl-CoA desaturase
Ligand
BDBM50060648
Substrate
n/a
Meas. Tech.
ChEMBL_1462110 (CHEMBL3396817)
IC50
945±n/a nM
Citation
 Sun, S; Zhang, Z; Pokrovskaia, N; Chowdhury, S; Jia, Q; Chang, E; Khakh, K; Kwan, R; McLaren, DG; Radomski, CC; Ratkay, LG; Fu, J; Dales, NA; Winther, MD Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem 23:455-65 (2015) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50060648
Synonyms:
CHEMBL3394687
Type:
Small organic molecule
Emp. Form.:
C14H12FN5O2S
Mol. Mass.:
333.341
SMILES:
Cc1nc(sc1C(N)=O)-n1cnn(Cc2ccc(F)cc2)c1=O
Structure:
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