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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50060769
Substrate
n/a
Meas. Tech.
ChEMBL_1462152 (CHEMBL3396926)
IC50
10.00±n/a nM
Citation
 Zak, M; Liederer, BM; Sampath, D; Yuen, PW; Bair, KW; Baumeister, T; Buckmelter, AJ; Clodfelter, KH; Cheng, E; Crocker, L; Fu, B; Han, B; Li, G; Ho, YC; Lin, J; Liu, X; Ly, J; O'Brien, T; Reynolds, DJ; Skelton, N; Smith, CC; Tay, S; Wang, W; Wang, Z; Xiao, Y; Zhang, L; Zhao, G; Zheng, X; Dragovich, PS Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorg Med Chem Lett 25:529-41 (2015) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50060769
Synonyms:
CHEMBL3394736
Type:
Small organic molecule
Emp. Form.:
C20H13F2N3O3S
Mol. Mass.:
413.397
SMILES:
[O-][S+](c1ccc(CNC(=O)c2cc3ccncc3o2)nc1)c1cc(F)cc(F)c1
Structure:
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