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Target
Cytochrome P450 26A1
Ligand
BDBM50063070
Substrate
n/a
Meas. Tech.
ChEMBL_1462611 (CHEMBL3399274)
IC50
3090±n/a nM
Citation
 Zhao, D; Sun, B; Ren, J; Li, F; Song, S; Lv, X; Hao, C; Cheng, M Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1). Bioorg Med Chem 23:1356-65 (2015) [PubMed]  Article 
Target
Name:
Cytochrome P450 26A1
Synonyms:
CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56216.16
Organism:
Homo sapiens (Human)
Description:
O43174
Residue:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
  
Inhibitor
Name:
BDBM50063070
Synonyms:
CHEMBL3398408
Type:
Small organic molecule
Emp. Form.:
C17H19NO4
Mol. Mass.:
301.3371
SMILES:
Cc1cc(C(=O)NC(CC(O)=O)c2ccc(C)cc2)c(C)o1
Structure:
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