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Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM50064639
Substrate
n/a
Meas. Tech.
ChEMBL_1465032 (CHEMBL3405048)
IC50
104±n/a nM
Citation
 Esteve, C; González, J; Gual, S; Vidal, L; Alzina, S; Sentellas, S; Jover, I; Horrillo, R; De Alba, J; Miralpeix, M; Tarrasón, G; Vidal, B Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma. Bioorg Med Chem Lett 25:1217-22 (2015) [PubMed]  Article 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM50064639
Synonyms:
CHEMBL3403751
Type:
Small organic molecule
Emp. Form.:
C20H15ClFN3O
Mol. Mass.:
367.804
SMILES:
COc1cc(C)c(cn1)-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl
Structure:
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