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Target
Bcl-2-like protein 1
Ligand
BDBM50066791
Substrate
n/a
Meas. Tech.
ChEMBL_1465965 (CHEMBL3406793)
Ki
17±n/a nM
Citation
 Levoin, N; Vo, DD; Gautier, F; Barillé-Nion, S; Juin, P; Tasseau, O; Grée, R A combination of in silico and SAR studies to identify binding hot spots of Bcl-xL inhibitors. Bioorg Med Chem 23:1747-57 (2015) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50066791
Synonyms:
CHEMBL3400492
Type:
Small organic molecule
Emp. Form.:
C38H31N3O3S
Mol. Mass.:
609.736
SMILES:
CCOC(=O)C1=C(C)C(c2ccccc2)n2c(=N1)s\c(=C\n1cc(Cc3ccc(cc3)-c3ccccc3)c3ccccc13)c2=O |c:5,17|
Structure:
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