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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50075195
Substrate
n/a
Meas. Tech.
ChEMBL_1473513 (CHEMBL3420196)
EC50
60±n/a nM
Citation
 Chen, X; Klöckner, J; Holze, J; Zimmermann, C; Seemann, WK; Schrage, R; Bock, A; Mohr, K; Tränkle, C; Holzgrabe, U; Decker, M Rational design of partial agonists for the muscarinic m1 acetylcholine receptor. J Med Chem 58:560-76 (2015) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50075195
Synonyms:
CHEMBL3414847
Type:
Small organic molecule
Emp. Form.:
C38H44FN3O5S
Mol. Mass.:
673.836
SMILES:
CC[C@@H]1SC2(CCNCC2)N(CCCCCCCCOc2ccc3cc(Cn4cc(C(O)=O)c(=O)c5cccc(F)c45)ccc3c2)C1=O |r|
Structure:
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