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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50346863
Substrate
n/a
Meas. Tech.
ChEMBL_1472635 (CHEMBL3418204)
IC50
31±n/a nM
Citation
 Valente, S; Rodriguez, V; Mercurio, C; Vianello, P; Saponara, B; Cirilli, R; Ciossani, G; Labella, D; Marrocco, B; Monaldi, D; Ruoppolo, G; Tilset, M; Botrugno, OA; Dessanti, P; Minucci, S; Mattevi, A; Varasi, M; Mai, A Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. Eur J Med Chem 94:163-74 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50346863
Synonyms:
CHEMBL1797640 | US8765820, 5b
Type:
Small organic molecule
Emp. Form.:
C16H16N2O
Mol. Mass.:
252.311
SMILES:
NC1CC1c1ccc(NC(=O)c2ccccc2)cc1
Structure:
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