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Target
Dual specificity mitogen-activated protein kinase kinase 1
Ligand
BDBM50094313
Substrate
n/a
Meas. Tech.
ChEMBL_1503906 (CHEMBL3593139)
IC50
>1000±n/a nM
Citation
 Ward, RA; Colclough, N; Challinor, M; Debreczeni, JE; Eckersley, K; Fairley, G; Feron, L; Flemington, V; Graham, MA; Greenwood, R; Hopcroft, P; Howard, TD; James, M; Jones, CD; Jones, CR; Renshaw, J; Roberts, K; Snow, L; Tonge, M; Yeung, K Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem 58:4790-801 (2015) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2
Type:
Other Protein Type
Mol. Mass.:
43439.03
Organism:
Homo sapiens (Human)
Description:
Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
  
Inhibitor
Name:
BDBM50094313
Synonyms:
CHEMBL3590109
Type:
Small organic molecule
Emp. Form.:
C14H20N4O3S
Mol. Mass.:
324.399
SMILES:
C=CS(=O)(=O)N1CCc2cnc(NC3CCOCC3)nc2C1
Structure:
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