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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50096218
Substrate
n/a
Meas. Tech.
ChEMBL_1505777 (CHEMBL3595015)
IC50
2.1±n/a nM
Citation
 Takahashi, B; Funami, H; Iwaki, T; Maruoka, H; Shibata, M; Koyama, M; Nagahira, A; Kamiide, Y; Kanki, S; Igawa, Y; Muto, T Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model. Bioorg Med Chem 23:4792-803 (2015) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR_RAT | Ghrelin receptor | Ghsr | Growth hormone secretagogue receptor type 1
Type:
PROTEIN
Mol. Mass.:
40970.19
Organism:
Rattus norvegicus
Description:
ChEMBL_11556
Residue:
364
Sequence:
MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
  
Inhibitor
Name:
BDBM50096218
Synonyms:
CHEMBL3593633
Type:
Small organic molecule
Emp. Form.:
C33H36N4O4
Mol. Mass.:
552.6633
SMILES:
[H][C@]12CC[C@]([H])(CC(=C1)c1cnc(NCc3ccc4CCOc4c3)c(c1)C(=O)NCCOc1ccccc1)N(C2)C(C)=O |r,c:7,TLB:9:7:38.39:3.2,THB:40:38:3.2:7.6.8|
Structure:
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