Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50097887
Substrate
n/a
Meas. Tech.
ChEMBL_1502265 (CHEMBL3591344)
IC50
11200±n/a nM
Citation
 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2). Bioorg Med Chem 23:4034-49 (2015) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
CCR2_MOUSE | Ccr2 | Cmkbr2
Type:
PROTEIN
Mol. Mass.:
42795.68
Organism:
Mus musculus
Description:
ChEMBL_1502265
Residue:
373
Sequence:
MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
  
Inhibitor
Name:
BDBM50097887
Synonyms:
CHEMBL3589845
Type:
Small organic molecule
Emp. Form.:
C32H31F7N2O2
Mol. Mass.:
608.5896
SMILES:
Fc1ccc(cc1)C(CCN1CCC2(CC1)OCCc1ccccc21)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
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