Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50350476
Substrate
n/a
Meas. Tech.
ChEMBL_1482571 (CHEMBL3537392)
IC50
16600±n/a nM
Citation
 Wolman, AT; Gionfriddo, MR; Heindel, GA; Mukhija, P; Witkowski, S; Bommareddy, A; Vanwert, AL Organic anion transporter 3 interacts selectively with lipophilicß-lactam antibiotics. Drug Metab Dispos 41:791-800 (2013) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Oat3 | Oat3 | Organic anion transporter 3 | Reduced in osteosclerosis transporter | Roct | S22A8_MOUSE | Slc22a8 | Solute carrier family 22 member 8 | mOat3
Type:
PROTEIN
Mol. Mass.:
59254.18
Organism:
Mus musculus
Description:
ChEMBL_104613
Residue:
537
Sequence:
MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGPNGKPEKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIEDIQDWYQQTKKTKQEPEAEKASQTIPLKTGGP
  
Inhibitor
Name:
BDBM50350476
Synonyms:
BRL-1702 | DICLOXACILLIN
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O5S
Mol. Mass.:
470.326
SMILES:
Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C(O)=O)-c1c(Cl)cccc1Cl |r,wU:15.21,wD:10.17,9.9,(11.49,-12.78,;10.14,-12.05,;8.75,-12.71,;7.65,-11.59,;8.43,-10.25,;9.94,-10.53,;11.05,-9.46,;10.68,-7.96,;12.52,-9.89,;13.63,-8.83,;15.18,-8.87,;16.63,-9.38,;17.56,-8.15,;18.74,-7.15,;18.67,-9.2,;16.69,-6.88,;15.22,-7.32,;13.68,-7.3,;12.61,-6.19,;17.19,-5.43,;16.19,-4.27,;18.7,-5.15,;7.78,-8.84,;8.55,-7.5,;10.1,-7.49,;7.77,-6.17,;6.22,-6.18,;5.47,-7.52,;6.25,-8.85,;5.48,-10.2,)|
Structure:
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