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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50350421
Substrate
n/a
Meas. Tech.
ChEMBL_1510493 (CHEMBL3607519)
IC50
13±n/a nM
Citation
 Djigoué, GB; Kenmogne, LC; Roy, J; Maltais, R; Poirier, D Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem 23:5433-51 (2015) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
DHB3_RAT | Edh17b3 | Hsd17b3 | Testosterone 17-beta-dehydrogenase 3
Type:
PROTEIN
Mol. Mass.:
34235.73
Organism:
Rattus norvegicus
Description:
ChEMBL_1510493
Residue:
306
Sequence:
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
  
Inhibitor
Name:
BDBM50350421
Synonyms:
CHEMBL1813731
Type:
Small organic molecule
Emp. Form.:
C33H47F3N2O4S
Mol. Mass.:
624.797
SMILES:
C[C@@H]1CN([C@@H](C)CN1C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@H]23)C1)S(=O)(=O)c1ccccc1C(F)(F)F |r|
Structure:
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