Reaction Details Report a problem with these data
Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50116357
Substrate
n/a
Meas. Tech.
ChEMBL_1511510 (CHEMBL3606935)
Ki
750±n/a nM
Citation
 Evans, GB; Cameron, SA; Luxenburger, A; Guan, R; Suarez, J; Thomas, K; Schramm, VL; Tyler, PC Tight binding enantiomers of pre-clinical drug candidates. Bioorg Med Chem 23:5326-33 (2015) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50116357
Synonyms:
CHEMBL3604360
Type:
Small organic molecule
Emp. Form.:
C13H19N5OS
Mol. Mass.:
293.388
SMILES:
CSC[C@@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@H]1O |r|
Structure:
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