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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50119636
Substrate
n/a
Meas. Tech.
ChEMBL_1517988 (CHEMBL3618845)
EC50
1360±n/a nM
Citation
 Liu, B; Croy, CH; Hitchcock, SA; Allen, JR; Rao, Z; Evans, D; Bures, MG; McKinzie, DL; Watt, ML; Stuart Gregory, G; Hansen, MM; Hoogestraat, PJ; Jamison, JA; Okha-Mokube, FM; Stratford, RE; Turner, W; Bymaster, F; Felder, CC Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists. Bioorg Med Chem Lett 25:4158-63 (2015) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50119636
Synonyms:
CHEMBL3616497
Type:
Small organic molecule
Emp. Form.:
C27H28BrN3O3
Mol. Mass.:
522.434
SMILES:
COc1ccc(CCN\C(C)=N\c2ccc3C[C@@H](O)[C@H](NC(=O)c4ccc(Br)cc4)c3c2)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: