Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM50298704
Substrate
n/a
Meas. Tech.
ChEMBL_1519743 (CHEMBL3624222)
IC50
>30000±n/a nM
Citation
 Nomura, S; Endo-Umeda, K; Aoyama, A; Makishima, M; Hashimoto, Y; Ishikawa, M Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators. ACS Med Chem Lett 6:902-7 (2015) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50298704
Synonyms:
CHEMBL585552 | N-(4-(2-Phenylethyl)phenyl)phthalimide
Type:
Small organic molecule
Emp. Form.:
C22H17NO2
Mol. Mass.:
327.3759
SMILES:
O=C1N(C(=O)c2ccccc12)c1ccc(CCc2ccccc2)cc1
Structure:
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