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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50128235
Substrate
n/a
Meas. Tech.
ChEMBL_1523326 (CHEMBL3630137)
IC50
780±n/a nM
Citation
 Iwasaki, A; Ohno, O; Katsuyama, S; Morita, M; Sasazawa, Y; Dan, S; Simizu, S; Yamori, T; Suenaga, K Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. Bioorg Med Chem Lett 25:5295-8 (2015) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | Opgl | Osteoclast differentiation factor | Osteoprotegerin ligand | Rankl | Receptor activator of nuclear factor kappa-B ligand | TNF-related activation-induced cytokine | TNF11_MOUSE | Tnfsf11 | Trance | Tumor necrosis factor ligand superfamily member 11, membrane form | Tumor necrosis factor ligand superfamily member 11, soluble form
Type:
PROTEIN
Mol. Mass.:
35008.20
Organism:
Mus musculus
Description:
ChEMBL_109846
Residue:
316
Sequence:
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
  
Inhibitor
Name:
BDBM50128235
Synonyms:
CHEMBL3628709
Type:
Small organic molecule
Emp. Form.:
C47H78N6O7
Mol. Mass.:
839.1582
SMILES:
CC[C@H](C)[C@H](N(C)C(=O)[C@H]([C@@H](C)CC)N(C)C(=O)C(\C)=C\CCCC#C)C(=O)N(C)[C@@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CC |r|
Structure:
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