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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50130202
Substrate
n/a
Meas. Tech.
ChEMBL_1524431 (CHEMBL3632439)
Ki
>50000±n/a nM
Citation
 Wang, G; Wang, Y; Wang, L; Han, L; Hou, X; Fu, H; Fang, H Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. Bioorg Med Chem 23:7359-65 (2015) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50130202
Synonyms:
CHEMBL3629649
Type:
Small organic molecule
Emp. Form.:
C24H20FN3O4
Mol. Mass.:
433.4317
SMILES:
OC(=O)[C@H](Cc1ccccc1)N1C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(F)c2)C1=O |r|
Structure:
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