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Target
Dihydrofolate reductase
Ligand
BDBM50134784
Substrate
n/a
Meas. Tech.
ChEMBL_1539069 (CHEMBL3738285)
IC50
4.0±n/a nM
Citation
 Chao, B; Li, BX; Xiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm 6:510-520 (2015) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50134784
Synonyms:
CHEMBL526243 | TCMDC-137820
Type:
Small organic molecule
Emp. Form.:
C18H14N6
Mol. Mass.:
314.344
SMILES:
Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1
Structure:
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