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Target
Dihydrofolate reductase
Ligand
BDBM50049904
Substrate
n/a
Meas. Tech.
ChEMBL_1539066 (CHEMBL3738282)
Ki
1.000000±n/a nM
Citation
 Chao, B; Li, BX; Xiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm 6:510-520 (2015) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50049904
Synonyms:
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL353764 | TCMDC-124301
Type:
Small organic molecule
Emp. Form.:
C10H9N5
Mol. Mass.:
199.212
SMILES:
Nc1nc(N)c2c3cc[nH]c3ccc2n1
Structure:
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