Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50138277
Substrate
n/a
Meas. Tech.
ChEMBL_1549892 (CHEMBL3758041)
IC50
700±n/a nM
Citation
 Brown, GD; Shi, Q; Delucca, GV; Batt, DG; Galella, MA; Cvijic, ME; Liu, RQ; Qiu, F; Zhao, Q; Barrish, JC; Carter, PH Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity. Bioorg Med Chem Lett 26:662-6 (2016) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50138277
Synonyms:
CHEMBL3754119
Type:
Small organic molecule
Emp. Form.:
C15H17ClO2
Mol. Mass.:
264.747
SMILES:
C[C@H]1CC=C(C(O)=O)[C@@](C)(C1)c1ccc(Cl)cc1 |r,t:3|
Structure:
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