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Target
Sphingosine kinase 1
Ligand
BDBM50139650
Substrate
n/a
Meas. Tech.
ChEMBL_1553854 (CHEMBL3767368)
Ki
13000±n/a nM
Citation
 Aurelio, L; Scullino, CV; Pitman, MR; Sexton, A; Oliver, V; Davies, L; Rebello, RJ; Furic, L; Creek, DJ; Pitson, SM; Flynn, BL From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II). J Med Chem 59:965-84 (2016) [PubMed]  Article 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM50139650
Synonyms:
CHEMBL3546834 | US9688668, 50
Type:
Small organic molecule
Emp. Form.:
C21H31N5O
Mol. Mass.:
369.5037
SMILES:
CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@H]1CCCN1C(N)=N |r|
Structure:
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