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Target
Solute carrier family 13 member 2
Ligand
BDBM50149244
Substrate
n/a
Meas. Tech.
ChEMBL_1557734 (CHEMBL3773093)
IC50
13200±n/a nM
Citation
 Huard, K; Gosset, JR; Montgomery, JI; Gilbert, A; Hayward, MM; Magee, TV; Cabral, S; Uccello, DP; Bahnck, K; Brown, J; Purkal, J; Gorgoglione, M; Lanba, A; Futatsugi, K; Herr, M; Genung, NE; Aspnes, G; Polivkova, J; Garcia-Irizarry, CN; Li, Q; Canterbury, D; Niosi, M; Vera, NB; Li, Z; Khunte, B; Siderewicz, J; Rolph, T; Erion, DM Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem 59:1165-75 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 13 member 2
Synonyms:
NADC1 | NADC1 | Na(+)/dicarboxylate cotransporter 1 | NaDC-1 | Renal sodium/dicarboxylate cotransporter | S13A2_HUMAN | SDCT1 | SLC13A2 | Solute carrier family 13 member 2
Type:
PROTEIN
Mol. Mass.:
64412.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_114812
Residue:
592
Sequence:
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP
  
Inhibitor
Name:
BDBM50149244
Synonyms:
CHEMBL3771118
Type:
Small organic molecule
Emp. Form.:
C13H17NO6
Mol. Mass.:
283.2772
SMILES:
COc1ncc(C)cc1CC[C@@](O)(CC(O)=O)C(O)=O |r|
Structure:
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