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Target
Presenilin-1
Ligand
BDBM50150510
Substrate
n/a
Meas. Tech.
ChEMBL_1558598 (CHEMBL3774087)
IC50
380±n/a nM
Citation
 Shi, J; Zuev, D; Xu, L; Lentz, KA; Grace, JE; Toyn, JH; Olson, RE; Macor, JE; Thompson, LA Design and optimization of tricyclic gamma-secretase modulators. Bioorg Med Chem Lett 26:1498-502 (2016) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50150510
Synonyms:
CHEMBL3769470
Type:
Small organic molecule
Emp. Form.:
C27H25N3O2
Mol. Mass.:
423.5063
SMILES:
COc1ccc(Cc2nc3c(CCc4cc(ccc4C3=O)-c3ccnc(C)c3)n2C)cc1
Structure:
Search PDB for entries with ligand similarity: