Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50152844
Substrate
n/a
Meas. Tech.
ChEMBL_1563482 (CHEMBL3783167)
Ki
119±n/a nM
Citation
 Gadhiya, S; Madapa, S; Kurtzman, T; Alberts, IL; Ramsey, S; Pillarsetty, NK; Kalidindi, T; Harding, WW Tetrahydroprotoberberine alkaloids with dopamine ands receptor affinity. Bioorg Med Chem 24:2060-71 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50152844
Synonyms:
CHEMBL3780140
Type:
Small organic molecule
Emp. Form.:
C24H31NO4
Mol. Mass.:
397.5072
SMILES:
CCCCCOc1ccc2CC3N(CCc4cc(OC)c(O)cc34)Cc2c1OC
Structure:
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