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Target
Pannexin-1
Ligand
BDBM50206509
Substrate
n/a
Meas. Tech.
ChEMBL_1564791 (CHEMBL3784394)
IC50
150000±n/a nM
Citation
 Baldwin, AG; Brough, D; Freeman, S Inhibiting the Inflammasome: A Chemical Perspective. J Med Chem 59:1691-710 (2016) [PubMed]  Article 
Target
Name:
Pannexin-1
Synonyms:
MRS1 | PANX1 | PANX1_HUMAN | Pannexin-1
Type:
PROTEIN
Mol. Mass.:
48047.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116759
Residue:
426
Sequence:
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
  
Inhibitor
Name:
BDBM50206509
Synonyms:
4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfamoyl-benzoic acid anion | 4-Dipropylsulfamoyl-benzoic acid(probenecid) | Benemid | CHEMBL897 | PROBENECID | Probalan
Type:
Small organic molecule
Emp. Form.:
C13H19NO4S
Mol. Mass.:
285.359
SMILES:
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
Structure:
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