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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50161198
Substrate
n/a
Meas. Tech.
ChEMBL_1566191 (CHEMBL3788097)
EC50
>20000±n/a nM
Citation
 Xue, Y; Tang, J; Ma, X; Li, Q; Xie, B; Hao, Y; Jin, H; Wang, K; Zhang, G; Zhang, L; Zhang, L Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. Eur J Med Chem 115:94-108 (2016) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50161198
Synonyms:
CHEMBL3787416
Type:
Small organic molecule
Emp. Form.:
C15H18N4O
Mol. Mass.:
270.3296
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1cnc2ccccn12 |r,wD:3.2,(1.42,-3.61,;2.24,-2.69,;3.74,-3,;4.23,-4.46,;3.13,-5.64,;3.63,-7.17,;5.21,-7.5,;6.3,-6.3,;5.81,-4.76,;4.62,-5.25,;4.98,-6.45,;1.75,-1.23,;2.65,.02,;1.75,1.23,;.3,.77,;-1.03,1.55,;-2.37,.77,;-2.37,-.77,;-1.03,-1.55,;.3,-.77,)|
Structure:
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