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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50007677
Substrate
n/a
Meas. Tech.
ChEMBL_1572971 (CHEMBL3801685)
Ki
125±n/a nM
Citation
 Lütnant, I; Schepmann, D; Wünsch, B Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists. Eur J Med Chem 116:136-146 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50007677
Synonyms:
(+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | (-)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | 4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | CHEMBL319706 | Ifenprodil
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Structure:
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