Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50168050
Substrate
n/a
Meas. Tech.
ChEMBL_1575695 (CHEMBL3804704)
IC50
26050±n/a nM
Citation
 Yang, L; Wang, W; Sun, Q; Xu, F; Niu, Y; Wang, C; Liang, L; Xu, P Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg Med Chem Lett 26:2801-2805 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50168050
Synonyms:
CHEMBL3799436
Type:
Small organic molecule
Emp. Form.:
C40H40N2O2P
Mol. Mass.:
611.731
SMILES:
CC(C)Cn1nc(-c2ccc(OCCCC[P+](c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: