Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-1
Ligand
BDBM50168050
Substrate
n/a
Meas. Tech.
ChEMBL_1575696 (CHEMBL3804705)
IC50
80200±n/a nM
Citation
 Yang, L; Wang, W; Sun, Q; Xu, F; Niu, Y; Wang, C; Liang, L; Xu, P Development of novel proteasome inhibitors based on phthalazinone scaffold. Bioorg Med Chem Lett 26:2801-2805 (2016) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50168050
Synonyms:
CHEMBL3799436
Type:
Small organic molecule
Emp. Form.:
C40H40N2O2P
Mol. Mass.:
611.731
SMILES:
CC(C)Cn1nc(-c2ccc(OCCCC[P+](c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c2ccccc2c1=O
Structure:
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