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Target
Sodium/nucleoside cotransporter 2
Ligand
BDBM50172392
Substrate
n/a
Meas. Tech.
ChEMBL_1579907 (CHEMBL3813163)
IC50
1500±n/a nM
Citation
 Tatani, K; Hiratochi, M; Kikuchi, N; Kuramochi, Y; Watanabe, S; Yamauchi, Y; Itoh, F; Isaji, M; Shuto, S Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout. J Med Chem 59:3719-31 (2016) [PubMed]  Article 
Target
Name:
Sodium/nucleoside cotransporter 2
Synonyms:
CNT 2 | Cnt2 | Cnt2 | Concentrative nucleoside transporter 2 | Na(+)/nucleoside cotransporter 2 | S28A2_RAT | Slc28a2 | Sodium-coupled nucleoside transporter 2 | Sodium/nucleoside cotransporter 2 | Sodium/purine nucleoside cotransporter | Solute carrier family 28 member 2 | Spnt | rCNT2
Type:
PROTEIN
Mol. Mass.:
72627.77
Organism:
Rattus norvegicus
Description:
ChEMBL_103618
Residue:
659
Sequence:
MAKSEGRKSASQDTSENGMENPGLELMEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRILQPFTKARSFYQRHAGLFKKILLGLLCLAYAAYLLAACILNFRRALALFVITCLVIFILACHFLKKFFAKKSIRCLKPLKNTRLRLWLKRVFMGAAVVGLILWLALDTAQRPEQLISFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVQSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIALVANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIGITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGILYVPRGAETDCVSFLNTNFTNRTYETYVCCRELFQSTLLNGTNMPSFSGPWQDKESSLRNLAKCCDLYTSTVCA
  
Inhibitor
Name:
BDBM50172392
Synonyms:
CHEMBL3808747
Type:
Small organic molecule
Emp. Form.:
C29H33N3O6
Mol. Mass.:
519.5888
SMILES:
OCCCCOc1cc(CNc2nc3ccccc3n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)ccc1-c1ccccc1 |r|
Structure:
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