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Target
Potassium channel subfamily K member 10
Ligand
BDBM50180656
Substrate
n/a
Meas. Tech.
ChEMBL_1584400 (CHEMBL3819943)
EC50
30000±n/a nM
Citation
 Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem 59:5149-57 (2016) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 10
Synonyms:
KCNK10 | KCNKA_HUMAN | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | TREK2
Type:
PROTEIN
Mol. Mass.:
59774.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105637
Residue:
538
Sequence:
MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
  
Inhibitor
Name:
BDBM50180656
Synonyms:
CHEMBL3818503
Type:
Small organic molecule
Emp. Form.:
C18H17Cl2N5
Mol. Mass.:
374.267
SMILES:
CC1(C)c2cc(Cl)ccc2N(CCc2nnn[nH]2)c2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: