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Target
Potassium two pore domain channel subfamily K member 2
Ligand
BDBM50180663
Substrate
n/a
Meas. Tech.
ChEMBL_1584412 (CHEMBL3819955)
IC50
750±n/a nM
Citation
 Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem 59:5149-57 (2016) [PubMed]  Article 
Target
Name:
Potassium two pore domain channel subfamily K member 2
Synonyms:
Potassium channel subfamily K member 2
Type:
PROTEIN
Mol. Mass.:
45443.30
Organism:
Bos taurus
Description:
ChEMBL_620769
Residue:
411
Sequence:
MAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHACVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLASERDVLPSLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM50180663
Synonyms:
CHEBI:7572 | CHEMBL1275655
Type:
Small organic molecule
Emp. Form.:
C36H39N3O6
Mol. Mass.:
609.7114
SMILES:
COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1 |c:4,9|
Structure:
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