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Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50183447
Substrate
n/a
Meas. Tech.
ChEMBL_1586735 (CHEMBL3825052)
IC50
14000±n/a nM
Citation
 Butler, KV; Bohn, K; Hrycyna, CA; Jin, J Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. Medchemcomm 7:1016-1021 (2016) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50183447
Synonyms:
CHEMBL3823076
Type:
Small organic molecule
Emp. Form.:
C19H19NO2S
Mol. Mass.:
325.425
SMILES:
Oc1c(ccc2cccnc12)C(C1CCOCC1)c1cccs1
Structure:
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