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Target
Dipeptidyl peptidase 1
Ligand
BDBM50195235
Substrate
n/a
Meas. Tech.
ChEMBL_1617582 (CHEMBL3859651)
IC50
16±n/a nM
Citation
 Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem 59:9457-9472 (2016) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_CANLF | CTSC | Cathepsin C | Cathepsin J | DPP-I | DPPI | Dipeptidyl peptidase 1 | Dipeptidyl peptidase 1 exclusion domain chain | Dipeptidyl peptidase 1 heavy chain 1 | Dipeptidyl peptidase 1 heavy chain 2 | Dipeptidyl peptidase 1 heavy chain 3 | Dipeptidyl peptidase 1 heavy chain 4 | Dipeptidyl peptidase 1 light chain | Dipeptidyl peptidase I | Dipeptidyl peptidase I exclusion domain chain | Dipeptidyl peptidase I heavy chain 1 | Dipeptidyl peptidase I heavy chain 2 | Dipeptidyl peptidase I heavy chain 3 | Dipeptidyl peptidase I heavy chain 4 | Dipeptidyl peptidase I light chain | Dipeptidyl transferase
Type:
PROTEIN
Mol. Mass.:
49414.76
Organism:
Canis lupus familiaris
Description:
ChEMBL_116958
Residue:
435
Sequence:
DTPANCTHPELLGTWVFQVGPAGSRSVNCSVMGPPEKKVVVHLEKLDTAYDNFGNTGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGHKVTSYCNETMTGWVHDVLGRNWACFTGTKMGTTSEKAKVNTKHIERLQENNSNRLYKYNYEFVKAINTIQKSWTATRYIEYETLTLRDMMTRVGGRKIPRPKPTPLTAEIHEEISRLPTSWDWRNVRGTNFVSPVRNQASCGSCYAFASTAMLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYAGSDSPCKPNDCFRYYSSEYYYVGGFYGACNEALMKLELVRHGPMAVAFEVYDDFFHYQKGIYYHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGSRWGEDGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM50195235
Synonyms:
CHEMBL3900409 | US10287258, Example 2 | US10669245, Example 2 | US11117874, Example 2 | US11655221, Example 2 | US11680049, Example 2 | US20230278969, Example 2
Type:
Small organic molecule
Emp. Form.:
C23H24N4O4
Mol. Mass.:
420.4611
SMILES:
Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r|
Structure:
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