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Target
Sodium/hydrogen exchanger isoform 3
Ligand
BDBM50196789
Substrate
n/a
Meas. Tech.
ChEMBL_1618874 (CHEMBL3861043)
IC50
7.8±n/a nM
Citation
 Rackelmann, N; Matter, H; Englert, H; Follmann, M; Maier, T; Weston, J; Arndt, P; Heyse, W; Mertsch, K; Wirth, K; Bialy, L Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na J Med Chem 59:8812-8829 (2016) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger isoform 3
Synonyms:
NHE3 | Sodium/hydrogen exchanger isoform 3
Type:
PROTEIN
Mol. Mass.:
15783.83
Organism:
Sus scrofa
Description:
ChEMBL_116993
Residue:
140
Sequence:
KYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWKWNTAFVLLTLVFISVYRVIGVVLQTWILNRYRMVQLEIIDQVVMSYGGLRGAVAFALVVLLDENKVKEKNLFVSTTLIVIFFTVIVQGLTIKPLV
  
Inhibitor
Name:
BDBM50196789
Synonyms:
CHEMBL3892788
Type:
Small organic molecule
Emp. Form.:
C23H24Cl3FN4O2
Mol. Mass.:
513.82
SMILES:
Cl.Cc1nnc(C)n1-c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CC[C@@H](O)C2)c(F)c1 |r|
Structure:
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