Reaction Details Report a problem with these data
Target
High affinity nerve growth factor receptor
Ligand
BDBM50111443
Substrate
n/a
Meas. Tech.
ChEMBL_1619560 (CHEMBL3861729)
EC50
22000±n/a nM
Citation
 Norman, BH; McDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem 60:66-88 (2017) [PubMed]  Article 
Target
Name:
High affinity nerve growth factor receptor
Synonyms:
High affinity nerve growth factor receptor | NTRK1_RAT | Neurotrophic tyrosine kinase receptor type 1 | Ntrk1 | Slow nerve growth factor receptor | Trk | Trk-A | Trka | p140-TrkA
Type:
PROTEIN
Mol. Mass.:
87865.88
Organism:
Rattus norvegicus
Description:
ChEMBL_100078
Residue:
799
Sequence:
MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG
  
Inhibitor
Name:
BDBM50111443
Synonyms:
2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540) | CHEMBL440470
Type:
Small organic molecule
Emp. Form.:
C14H11N3O5
Mol. Mass.:
301.2542
SMILES:
OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: