Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50203539
Substrate
n/a
Meas. Tech.
ChEMBL_1625735 (CHEMBL3868204)
IC50
4200±n/a nM
Citation
 Ouvry, G; Bouix-Peter, C; Ciesielski, F; Chantalat, L; Christin, O; Comino, C; Duvert, D; Feret, C; Harris, CS; Lamy, L; Luzy, AP; Musicki, B; Orfila, D; Pascau, J; Parnet, V; Perrin, A; Pierre, R; Polge, G; Raffin, C; Rival, Y; Taquet, N; Thoreau, E; Hennequin, LF Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists. Bioorg Med Chem Lett 26:5802-5808 (2016) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50203539
Synonyms:
CHEMBL3950318
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2N3O4S
Mol. Mass.:
528.407
SMILES:
OC(=O)c1ccc(cc1)-n1nc(Sc2c(Cl)cccc2Cl)c2cc(ccc12)C(=O)N1CCOCC1
Structure:
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