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Target
Sterol O-acyltransferase 2
Ligand
BDBM50204545
Substrate
n/a
Meas. Tech.
ChEMBL_1627619 (CHEMBL3870140)
IC50
9300±n/a nM
Citation
 Kobayashi, K; Ohshiro, T; Tomoda, H; Yin, F; Cui, HL; Chouthaiwale, PV; Tanaka, F Discovery of SOAT2 inhibitors from synthetic small molecules. Bioorg Med Chem Lett 26:5899-5901 (2016) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACAT-2 | ACAT2 | Acyl-coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | SOAT2 | SOAT2_CHLAE | Sterol O-acyltransferase 2
Type:
PROTEIN
Mol. Mass.:
60426.29
Organism:
Chlorocebus aethiops
Description:
ChEMBL_116979
Residue:
526
Sequence:
MEPGGARLRLQRTEGPGGEREHQPCRDGNTETHRAPDLVKWTRHMEAVKAQLLEQAQGQLRELLDRAMWEAIQSYPSQDKPPPLPPPDSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARPGARGTWTLGAGLGCALLAAHALVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYIRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGAQARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQHTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQTTFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50204545
Synonyms:
CHEMBL3898917
Type:
Small organic molecule
Emp. Form.:
C16H18BrNO3
Mol. Mass.:
352.223
SMILES:
CCC[C@@H]1CC(=O)C[C@@]2(O1)C(=O)N(C)c1cccc(Br)c21 |r|
Structure:
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