Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM50205623
Substrate
n/a
Meas. Tech.
ChEMBL_1628501 (CHEMBL3871086)
IC50
185000±n/a nM
Citation
 Barros, TG; Santos, JAN; de Souza, BEG; Sodero, ACR; de Souza, AMT; da Silva, DP; Rodrigues, CR; Pinheiro, S; Dias, LRS; Abrahim-Vieira, B; Puzer, L; Muri, EMF Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor. Bioorg Med Chem Lett 27:314-318 (2017) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM50205623
Synonyms:
CHEMBL3951954
Type:
Small organic molecule
Emp. Form.:
C31H39FN2O5
Mol. Mass.:
538.6502
SMILES:
[H][C@]12OC[C@H](N(C(=O)Cc3ccc(F)cc3)C(C)(C)C(=O)NC3CCCCC3)[C@@]1([H])OC[C@H]2OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: