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Target
MAP/microtubule affinity-regulating kinase 4
Ligand
BDBM50208929
Substrate
n/a
Meas. Tech.
ChEMBL_1633232 (CHEMBL3876024)
IC50
>10000±n/a nM
Citation
 Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg Med Chem Lett 27:114-120 (2017) [PubMed]  Article 
Target
Name:
MAP/microtubule affinity-regulating kinase 4
Synonyms:
KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1
Type:
PROTEIN
Mol. Mass.:
82561.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774620
Residue:
752
Sequence:
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
  
Inhibitor
Name:
BDBM50208929
Synonyms:
CHEMBL3883776
Type:
Small organic molecule
Emp. Form.:
C18H18N6O
Mol. Mass.:
334.3751
SMILES:
Cn1cc(cn1)N1C(=O)c2nc(Nc3ccccc3)ncc2C1(C)C
Structure:
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