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Target
Translocator protein
Ligand
BDBM50210866
Substrate
n/a
Meas. Tech.
ChEMBL_1635026 (CHEMBL3877924)
Ki
0.260000±n/a nM
Citation
 Cacheux, F; Médran-Navarrete, V; Dollé, F; Marguet, F; Puech, F; Damont, A Synthesis and in vitro characterization of novel fluorinated derivatives of the translocator protein 18 kDa ligand CfO-DPA-714. Eur J Med Chem 125:346-359 (2017) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50210866
Synonyms:
CHEMBL3979767
Type:
Small organic molecule
Emp. Form.:
C25H33FN4O
Mol. Mass.:
424.5541
SMILES:
CCCN(CCC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(CCCF)cc1
Structure:
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