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Target
Methionine aminopeptidase 1
Ligand
BDBM50211290
Substrate
n/a
Meas. Tech.
ChEMBL_1636403 (CHEMBL3879301)
IC50
>15000±n/a nM
Citation
 Helgren, TR; Chen, C; Wangtrakuldee, P; Edwards, TE; Staker, BL; Abendroth, J; Sankaran, B; Housley, NA; Myler, PJ; Audia, JP; Horn, JR; Hagen, TJ Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem 25:813-824 (2017) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50211290
Synonyms:
CHEMBL2407096
Type:
Small organic molecule
Emp. Form.:
C13H18N4S
Mol. Mass.:
262.374
SMILES:
CC(C)(C)c1ccc(CSc2nnc(N)[nH]2)cc1
Structure:
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