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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50217978
Substrate
n/a
Meas. Tech.
ChEMBL_2529 (CHEMBL616879)
Ki
126±n/a nM
Citation
 Bromidge, SM; Dabbs, S; Davies, S; Duckworth, DM; Forbes, IT; Jones, GE; Jones, J; King, FD; Saunders, DV; Blackburn, TP; Holland, V; Kennett, GA; Lightowler, S; Middlemiss, DN; Riley, GJ; Trail, B; Wood, MD 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents. Bioorg Med Chem Lett 10:1863-6 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50217978
Synonyms:
CHEMBL53152
Type:
Small organic molecule
Emp. Form.:
C21H16BrF3N4O2
Mol. Mass.:
493.277
SMILES:
Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(cc23)C(F)(F)F)cn1
Structure:
Search PDB for entries with ligand similarity: