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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM50219333
Substrate
n/a
Meas. Tech.
ChEMBL_154565 (CHEMBL761913)
IC50
2310±n/a nM
Citation
 Barnes, MJ; Cooper, N; Davenport, RJ; Dyke, HJ; Galleway, FP; Galvin, FC; Gowers, L; Haughan, AF; Lowe, C; Meissner, JW; Montana, JG; Morgan, T; Picken, CL; Watson, RJ Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors. Bioorg Med Chem Lett 11:1081-3 (2001) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
Phosphodiesterase 7
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 302392
Components:
This complex has 2 components.
Component 1
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Component 2
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM50219333
Synonyms:
CHEMBL11073
Type:
Small organic molecule
Emp. Form.:
C15H13BrN6O3
Mol. Mass.:
405.206
SMILES:
Nc1nc(O)c2nc(Br)n(C3CCCc4ccc(cc34)[N+]([O-])=O)c2n1
Structure:
Search PDB for entries with ligand similarity: