Reaction Details Report a problem with these data
Target
Sphingomyelin phosphodiesterase [1-45,48-631]
Ligand
BDBM50221659
Substrate
n/a
Meas. Tech.
ChEMBL_27394 (CHEMBL644937)
IC50
102000±n/a nM
Citation
 Hamada, M; Iikubo, K; Ishikawa, Y; Ikeda, A; Umezawa, K; Nishiyama, S Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase. Bioorg Med Chem Lett 13:3151-3 (2003) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase [1-45,48-631]
Synonyms:
ASM | ASM_HUMAN | SMPD1 | Sphingomyelin phosphodiesterase
Type:
PROTEIN
Mol. Mass.:
69760.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_27393
Residue:
629
Sequence:
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC
  
Inhibitor
Name:
BDBM50221659
Synonyms:
CHEMBL107844
Type:
Small organic molecule
Emp. Form.:
C19H18O6
Mol. Mass.:
342.3426
SMILES:
[#6]-[#8]-c1cc2c(cc1-[#8])oc1cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c1c2=O
Structure:
Search PDB for entries with ligand similarity: